A September 2019 study by Dr. Hyon Choi, Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts found that, “…heart disease, like chronic kidney disease, is a risk factor for allopurinol-associated severe cutaneous adverse reactions that warrants adoption of precautionary measures against these reactions, such as low-dosage allopurinol initiation or screening for HLA-B*5801,"