Inflammation mechanisms relating to diabetes type 2 and obesity may be linked to changes (from elevated fat derivatives or defects) in mitochondria and not glucose. Researchers said, "Aggressive blood glucose control to lower the risk of diabetic complications has been the goal for most people with Type 2 Diabetes for decades … Our data provide an explanation for why people with tight glucose control can nonetheless have disease progression."

August 2019 study by University of Kentucky.