A March 2021 study by the American Heart Association concerning, “The possible mental health side effects of beta-blockers [which] have been the subject of discussion in the scientific community for many decades," 

“…our results showing beta-blockers are not the cause of so many of these negative side effects are quite consequential."

“Our results indicate that concerns about adverse mental health events, especially depression, should not affect the decision about beta blockers. Beta-blockers are mostly safe regarding psychological health," 

"We found no indication of an association between beta-blocker use and depression. The same was true for most of the other mental health symptoms, as reported in the studies that were included in our analyses. However, sleep-related symptoms such as unusual dreams or insomnia did emerge during beta?blocker therapy for some patients."

"Patients with a history of cardiovascular events such as a heart attack or stroke were prone to develop psychological complications. Though we found beta-blockers were not causally linked, these patients should be monitored."