An April 2021 report by the University of Waterloo said, 

"Because our immune system is affected by the circadian clock, our ability to mount an immune response changes during the day," 

"How likely are you to fight off an infection that occurs in the morning than midday? The answer depends on whether you are a man or a woman, and whether you are among quarter of the modern-day labour force that has an irregular work schedule."

"Shift work likely affects men and women differently," 

"Compared to females, the immune system in males is more prone to over-activation, which can increase their chances of sepsis following an ill-timed infection."