Ketogenic diet and Cognitive Behaviour, Blood Lipids and Motor Function

An April 2024 study by the University of California and Istinye University said,

• “intermittent ketogenic diet (IKD) or ketogenic diet (KD) intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats; however, both IKD and KD positively impacted circulating lipids.”

• “it remains to be determined whether long-term consumption of a ketogenic diet can mitigate declines in cognitive or motor behavior in a rat model of AD. Therefore, the current study aimed to determine whether a KD improves cognitive or motor behavior in the TgF344-AD rat.”

• “the IKD or KD did not improve motor coordination or spatial learning memory compared to the control diet. However, KD, and to a lesser extent IKD, mitigated elevations in plasma lipids in the TgF344-AD rats. Furthermore, the KD diet decreased plasma levels of total Tau in females.”

ketogenic diet and polycystic kidney disease (PKD)

A December 2023 study by the University of California, Santa Barbara said they were,

• “… really happy about these clinical trial results … We now have the first evidence in humans that the cysts really don’t like to be in ketosis and that they don’t seem to grow.”

•  “If you have PKD, the dogma is that it’s a genetic disease … And no matter what you do, you progress toward kidney failure and diet doesn’t make any difference, which unfortunately most patients are told to this day.”  

•  “To everyone’s great surprise, kidney function actually improved with the ketogenic diet … And that was a hard outcome of statistical significance.” 

•  “Doctors often assume that their patients cannot adhere to a diet anyway, so they don’t even try. Clearly, this is not true. People with PKD are highly motivated to do something about their condition,”  

•  “A keto diet just means very low carbs,”

• “If you make a discovery in animals, but you don’t check it in actual people, you’ll never quite know if it’s going to be meaningful … There’s always going to be the doubt, and people are going to say animal experiments don’t always translate to humans.”

Low-calorie ketogenic diet, testosterone, overweight men

A May 2021 study by the University of Bari said, 

"We aimed to evaluate the response of total testosterone and sex hormone levels to a very low-calorie ketogenic diet in a cohort of overweight or obese non-diabetic male subjects and what we found was that there is a noticeable relation between a specific, controlled diet and insulin action, energy balance, and testicular function,"